INHIBITION OF THE MAMMALIAN TARGET OF RAPAMYCIN BLOCKS EPILEPSY PROGRESSION IN NS-PTEN CONDITIONAL KNOCKOUT MICE

PURPOSE: Increased activity of mTOR Complex 1 (mTORC1) has been demonstrated in cortical dysplasia and tuberous sclerosis complex, as well as in animal models of epilepsy. Recent studies in such models revealed that inhibiting mTORC1 with rapamycin effectively suppressed seizure activity. However, s...

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Main Authors: Sunnen, C. Nicole, Brewster, Amy L., Lugo, Joaquin N., Vanegas, Fabiola, Turcios, Eric, Mukhi, Shivani, Parghi, Deena, D'Arcangelo, Gabriella, Anderson, Anne E.
格式: Artigo
語言:Inglês
出版: 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204180/
https://ncbi.nlm.nih.gov/pubmed/21973019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1528-1167.2011.03280.x
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