Norisoboldine Suppresses Osteoclast Differentiation through Preventing the Accumulation of TRAF6-TAK1 Complexes and Activation of MAPKs/NF-κB/c-Fos/NFATc1 Pathways

Norisoboldine (NOR) is the main alkaloid constituent in the dry root of Lindera aggregata (Sims) Kosterm. (L. strychnifolia Vill.). As reported previously, orally administered NOR displayed a robust inhibition of joint bone destruction present in both mouse collagen-induced arthritis and rat adjuvan...

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Bibliographic Details
Main Authors: Wei, Zhi-feng, Tong, Bei, Xia, Yu-feng, Lu, Qian, Chou, Gui-xin, Wang, Zheng-tao, Dai, Yue
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594163/
https://ncbi.nlm.nih.gov/pubmed/23536866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0059171
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