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Genetically-attenuated Plasmodium berghei liver-stages induce sterile protracted protection that is mediated by MHC class I-dependent IFN-γ producing CD8+ T cells
Presently, radiation-attenuated Plasmodia sporozoites (γ-spz) is the only vaccine that induces sterile and lasting protection in malaria-naïve humans and laboratory rodents. However, γ-spz are not without risks. For example, the heterogeneity of the γ-spz could explain occasional break-through infec...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3594113/ https://ncbi.nlm.nih.gov/pubmed/17624847 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/519743 |
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