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Design, synthesis and structure-activity relationship of rhenium 2-arylbenzothiazoles as β-amyloid plaque binding agents

To continue our efforts toward the development of (99m)Tc PiB analogs, we have synthesized twenty-four neutral and lipophilic Re (as a surrogate of (99m)Tc) 2-arylbenzothiazoles, and explored their structure-activity relationship for binding to Aβ(1–40)fibrils. These Re complexes were designed and s...

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Библиографические подробности
Главные авторы: Pan, Jinhe, Mason, Neale S., Debnath, Manik L., Mathis, Chester A., Klunk, William E., Lin, Kuo-Shyan
Формат: Artigo
Язык:Inglês
Опубликовано: 2013
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594088/
https://ncbi.nlm.nih.gov/pubmed/23411076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.01.068
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