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Design, synthesis and structure-activity relationship of rhenium 2-arylbenzothiazoles as β-amyloid plaque binding agents
To continue our efforts toward the development of (99m)Tc PiB analogs, we have synthesized twenty-four neutral and lipophilic Re (as a surrogate of (99m)Tc) 2-arylbenzothiazoles, and explored their structure-activity relationship for binding to Aβ(1–40)fibrils. These Re complexes were designed and s...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3594088/ https://ncbi.nlm.nih.gov/pubmed/23411076 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.01.068 |
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