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Transfection Efficiency and Transgene Expression Kinetics of mRNA Delivered in Naked and Nanoparticle Format

Transfection efficiencies and transgene expression kinetics of messenger RNA (mRNA), an emerging class of nucleic acid-based therapeutics, have been poorly characterized. In this study, we evaluated transfection efficiencies of mRNA delivered in naked and nanoparticle format in vitro and in vivo usi...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Phua, Kyle K.L, Leong, Kam W., Nair, Smita K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594075/
https://ncbi.nlm.nih.gov/pubmed/23306021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2012.12.029
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