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Suppression of mRNA Nanoparticle Transfection in Human Fibroblasts by Selected Interferon Inhibiting Small Molecule Compounds

In vitro transcribed (IVT) mRNA is increasingly applied in lieu of DNA to deliver reprogramming genes to fibroblasts for stem cell derivation. However, IVT mRNA induces interferon (IFN) responses from mammalian cells that reduces transfection efficiency. It has been previously suggested that small m...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Biomolecules
Egile Nagusiak: Liu, Yang, Krishnan, Manoj N., Phua, Kyle K. L.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: MDPI 2017
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5618237/
https://ncbi.nlm.nih.gov/pubmed/28758979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom7030056
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