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Synthesis and evaluation of methylsulfonylnitrobenzamides (MSNBAs) as inhibitors of the thyroid hormone receptor-coactivator interaction

We previously identified the methylsulfonylnitrobenzoates (MSNBs) that block the interaction of the thyroid hormone receptor with its obligate transcriptional coactivators and prevent thyroid hormone signaling. As part of our lead optimization work we demonstrated that sulfonylnitrophenylthiazoles (...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Hwang, Jong Yeon, Attia, Ramy R., Carrillo, Angela K., Connelly, Michele C., Guy, R. Kiplin
פורמט: Artigo
שפה:Inglês
יצא לאור: 2013
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594046/
https://ncbi.nlm.nih.gov/pubmed/23414840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.12.055
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