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Synthesis and evaluation of methylsulfonylnitrobenzamides (MSNBAs) as inhibitors of the thyroid hormone receptor-coactivator interaction

We previously identified the methylsulfonylnitrobenzoates (MSNBs) that block the interaction of the thyroid hormone receptor with its obligate transcriptional coactivators and prevent thyroid hormone signaling. As part of our lead optimization work we demonstrated that sulfonylnitrophenylthiazoles (...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Hwang, Jong Yeon, Attia, Ramy R., Carrillo, Angela K., Connelly, Michele C., Guy, R. Kiplin
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594046/
https://ncbi.nlm.nih.gov/pubmed/23414840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.12.055
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