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Phenotypic model for early T-cell activation displaying sensitivity, specificity, and antagonism
Early T-cell activation is selected by evolution to discriminate a few foreign peptides rapidly from a vast excess of self-peptides, and it is unclear in quantitative terms how this is possible. We show that a generic proofreading cascade supplemented by a single negative feedback mediated by the Sr...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3593884/ https://ncbi.nlm.nih.gov/pubmed/23431198 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1300752110 |
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