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Phenotypic model for early T-cell activation displaying sensitivity, specificity, and antagonism

Early T-cell activation is selected by evolution to discriminate a few foreign peptides rapidly from a vast excess of self-peptides, and it is unclear in quantitative terms how this is possible. We show that a generic proofreading cascade supplemented by a single negative feedback mediated by the Sr...

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Autori principali: François, Paul, Voisinne, Guillaume, Siggia, Eric D., Altan-Bonnet, Grégoire, Vergassola, Massimo
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3593884/
https://ncbi.nlm.nih.gov/pubmed/23431198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1300752110
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