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SOD1 exhibits allosteric frustration to facilitate metal binding affinity
Superoxide dismutase–1 (SOD1) is a ubiquitous, Cu and Zn binding, free-radical defense enzyme whose misfolding and aggregation play a potential key role in amyotrophic lateral sclerosis, an invariably fatal neurodegenerative disease. Over 150 mutations in SOD1 have been identified with a familial fo...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3593857/ https://ncbi.nlm.nih.gov/pubmed/23431152 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1216597110 |
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