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Transcriptional Modulation of the ERK1/2 MAPK and NF-κB Pathways in Human Urothelial Cells After Trivalent Arsenical Exposure: Implications for Urinary Bladder Cancer

Chronic exposure to drinking water contaminated with inorganic arsenic (iAs) is associated with an increased risk of urinary bladder (UB) cancers in humans. The exact role of specific iAs metabolite(s) in As-mediated carcinogenesis remains largely unknown. Experimental evidence suggests that trivale...

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Detalhes bibliográficos
Main Authors: Bailey, Kathryn A., Wallace, Kathleen, Smeester, Lisa, Thai, Sheau-Fung, Wolf, Douglas C., Edwards, Stephen W., Fry, Rebecca C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3593739/
https://ncbi.nlm.nih.gov/pubmed/23487506
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