Transformation properties of the E2a-Pbx1 chimeric oncoprotein: fusion with E2a is essential, but the Pbx1 homeodomain is dispensable.

The t(1;19) chromosomal translocation in acute lymphoblastic leukemias creates chimeric E2a-Pbx1 oncoproteins that can act as DNA-binding activators of transcription. A structural analysis of the functional domains of E2a-Pbx1 showed that portions of both E2a and Pbx1 were essential for transformati...

Полное описание

Библиографические подробности

Опубликовано в::	Mol Cell Biol
Главные авторы:	Monica, K, LeBrun, D P, Dedera, D A, Brown, R, Cleary, M L
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Taylor & Francis 1994
Предметы:	Research Article
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC359369/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7969166/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.14.12.8304-8314.1994
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