Transformation properties of the E2a-Pbx1 chimeric oncoprotein: fusion with E2a is essential, but the Pbx1 homeodomain is dispensable.

The t(1;19) chromosomal translocation in acute lymphoblastic leukemias creates chimeric E2a-Pbx1 oncoproteins that can act as DNA-binding activators of transcription. A structural analysis of the functional domains of E2a-Pbx1 showed that portions of both E2a and Pbx1 were essential for transformati...

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Publicado en:	Mol Cell Biol
Autores principales:	Monica, K, LeBrun, D P, Dedera, D A, Brown, R, Cleary, M L
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Taylor & Francis 1994
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC359369/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7969166/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.14.12.8304-8314.1994
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