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Multi-Site Prenylation of 4-Substituted Tryptophans by Dimethylallyltryptophan Synthase

The aromatic prenyltransferase dimethylallyltryptophan synthase in Claviceps purpurea catalyzes the normal prenylation of tryptophan at C4 of the indole nucleus in the first committed step of ergot alkaloid biosynthesis. 4-Methyltryptophan is a competitive inhibitor of the enzyme that has been used...

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Detalhes bibliográficos
Main Authors: Rudolf, Jeffrey D., Wang, Hong, Poulter, C. Dale
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3593668/
https://ncbi.nlm.nih.gov/pubmed/23301871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja310734n
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