PACAP Inhibits β-cell Mass Expansion in a Mouse Model of Type II Diabetes: Persistent Suppressive Effects on Islet Density

Pituitary adenylate cyclase-activating polypeptide (PACAP) is a potent insulinotropic G-protein-coupled receptor ligand, for which morphoregulative roles in pancreatic islets have recently been suggested. Here, we evaluated the effects of pancreatic overexpression of PACAP on morphometric changes of...

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Detalhes bibliográficos
Main Authors: Inoue, Hiroaki, Shintani, Norihito, Sakurai, Yusuke, Higashi, Shintaro, Hayata-Takano, Atsuko, Baba, Akemichi, Hashimoto, Hitoshi
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2013
Assuntos:
Endocrinology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3593608/
https://ncbi.nlm.nih.gov/pubmed/23483824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fendo.2013.00027
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