Detection and Quantification of Methylation in DNA using Solid-State Nanopores

Epigenetic modifications in eukaryotic genomes occur primarily in the form of 5-methylcytosine (5 mC). These modifications are heavily involved in transcriptional repression, gene regulation, development and the progression of diseases including cancer. We report a new single-molecule assay for the...

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Main Authors: Shim, Jiwook, Humphreys, Gwendolyn I., Venkatesan, Bala Murali, Munz, Jan Marie, Zou, Xueqing, Sathe, Chaitanya, Schulten, Klaus, Kosari, Farhad, Nardulli, Ann M., Vasmatzis, George, Bashir, Rashid
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3593219/
https://ncbi.nlm.nih.gov/pubmed/23474808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep01389
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