Transactivation of the human p53 tumor suppressor gene by c-Myc/Max contributes to elevated mutant p53 expression in some tumors.
Elevated levels of mutant forms of the p53 tumor suppressor are a hallmark of many transformed cells. Multiple mechanisms such as increased stability of the protein and increased transcription of the gene can account for elevated p53 expression. Recent findings indicate that c-Myc/Max heterodimers c...
Spremljeno u:
| Izdano u: | Mol Cell Biol |
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| Glavni autori: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Taylor & Francis
1994
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC359320/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7969121/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.14.12.7805-7815.1994 |
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