NLRP3 Plays a Critical Role in the Development of Experimental Autoimmune Encephalomyelitis by Mediating Th1 and Th17 Responses

The interplay between innate and adaptive immunity is important in multiple sclerosis (MS). The inflammasome complex, which activates caspase-1 to process pro–IL-1β and pro–IL-18, is rapidly emerging as a pivotal regulator of innate immunity, with nucleotide-binding domain, leucine-rich repeat conta...

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Detalhes bibliográficos
Main Authors: Gris, Denis, Ye, Zhengmao, Iocca, Heather A., Wen, Haitao, Craven, Robin R., Gris, Pavel, Huang, Max, Schneider, Monika, Miller, Stephen D., Ting, Jenny P.-Y.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3593010/
https://ncbi.nlm.nih.gov/pubmed/20574004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0904145
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