Phospholipid Metabolites in Recurrent Glioblastoma: In Vivo Markers Detect Different Tumor Phenotypes before and under Antiangiogenic Therapy

PURPOSE: Metabolic changes upon antiangiogenic therapy of recurrent glioblastomas (rGBMs) may provide new biomarkers for treatment efficacy. Since in vitro models showed that phospholipid membrane metabolism provides specific information on tumor growth we employed in-vivo MR-spectroscopic imaging (...

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Main Authors: Hattingen, Elke, Bähr, Oliver, Rieger, Johannes, Blasel, Stella, Steinbach, Joachim, Pilatus, Ulrich
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3592858/
https://ncbi.nlm.nih.gov/pubmed/23520454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0056439
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