An Alphavirus Vector-Based Tetravalent Dengue Vaccine Induces a Rapid and Protective Immune Response in Macaques That Differs Qualitatively from Immunity Induced by Live Virus Infection

Despite many years of research, a dengue vaccine is not available, and the more advanced live attenuated vaccine candidate in clinical trials requires multiple immunizations with long interdose periods and provides low protective efficacy. Here, we report important contributions to the development o...

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Detalhes bibliográficos
Main Authors: White, Laura J., Sariol, Carlos A., Mattocks, Melissa D., Wahala M. P. B., Wahala, Yingsiwaphat, Vorraphun, Collier, Martha L., Whitley, Jill, Mikkelsen, Rochelle, Rodriguez, Idia V., Martinez, Melween I., de Silva, Aravinda, Johnston, Robert E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3592161/
https://ncbi.nlm.nih.gov/pubmed/23302884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02298-12
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