An Alphavirus Vector-Based Tetravalent Dengue Vaccine Induces a Rapid and Protective Immune Response in Macaques That Differs Qualitatively from Immunity Induced by Live Virus Infection

Despite many years of research, a dengue vaccine is not available, and the more advanced live attenuated vaccine candidate in clinical trials requires multiple immunizations with long interdose periods and provides low protective efficacy. Here, we report important contributions to the development o...

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Główni autorzy: White, Laura J., Sariol, Carlos A., Mattocks, Melissa D., Wahala M. P. B., Wahala, Yingsiwaphat, Vorraphun, Collier, Martha L., Whitley, Jill, Mikkelsen, Rochelle, Rodriguez, Idia V., Martinez, Melween I., de Silva, Aravinda, Johnston, Robert E.
Format: Artigo
Język:Inglês
Wydane: American Society for Microbiology 2013
Hasła przedmiotowe:
Vaccines and Antiviral Agents
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3592161/
https://ncbi.nlm.nih.gov/pubmed/23302884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02298-12
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