The Virion Host Shutoff RNase Plays a Key Role in Blocking the Activation of Protein Kinase R in Cells Infected with Herpes Simplex Virus 1

Earlier studies have shown that active MEK blocks the activation of protein kinase R (PKR), a component of antiviral innate immune responses. In this report we show that the herpes simplex virus 1 virion host shutoff (VHS) RNase protein and MEK (mitogen-activated protein kinase kinase) act cooperati...

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Detaylı Bibliyografya
Asıl Yazarlar: Sciortino, Maria Teresa, Parisi, Tiziana, Siracusano, Gabriel, Mastino, Antonio, Taddeo, Brunella, Roizman, Bernard
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2013
Konular:
Virus-Cell Interactions
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3592158/
https://ncbi.nlm.nih.gov/pubmed/23302873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03049-12
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