Biophysical and Ultrastructural Characterization of Adeno-Associated Virus Capsid Uncoating and Genome Release

We describe biophysical and ultrastructural differences in genome release from adeno-associated virus (AAV) capsids packaging wild-type DNA, recombinant single-stranded DNA (ssDNA), or dimeric, self-complementary DNA (scDNA) genomes. Atomic force microscopy and electron microscopy (EM) revealed that...

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Bibliographische Detailangaben
Hauptverfasser: Horowitz, Eric D., Rahman, K. Shefaet, Bower, Brian D., Dismuke, David J., Falvo, Michael R., Griffith, Jack D., Harvey, Stephen C., Asokan, Aravind
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2013
Schlagworte:
Structure and Assembly
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3592113/
https://ncbi.nlm.nih.gov/pubmed/23269804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03017-12
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