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Gedunin Inactivates the Co-chaperone p23 Protein Causing Cancer Cell Death by Apoptosis

Pharmacological inhibition of Hsp90 is an exciting option for cancer therapy. The clinical efficacy of Hsp90 inhibitors is, however, less than expected. Binding of the co-chaperone p23 to Hsp90 and induced overexpression of anti-apoptotic proteins Hsp70 and Hsp27 are thought to contribute to this ou...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Patwardhan, Chaitanya A., Fauq, Abdul, Peterson, Laura B., Miller, Charles, Blagg, Brian S. J., Chadli, Ahmed
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2013
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3591639/
https://ncbi.nlm.nih.gov/pubmed/23355466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.427328
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