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Gedunin Inactivates the Co-chaperone p23 Protein Causing Cancer Cell Death by Apoptosis

Pharmacological inhibition of Hsp90 is an exciting option for cancer therapy. The clinical efficacy of Hsp90 inhibitors is, however, less than expected. Binding of the co-chaperone p23 to Hsp90 and induced overexpression of anti-apoptotic proteins Hsp70 and Hsp27 are thought to contribute to this ou...

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Bibliografiske detaljer
Main Authors: Patwardhan, Chaitanya A., Fauq, Abdul, Peterson, Laura B., Miller, Charles, Blagg, Brian S. J., Chadli, Ahmed
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3591639/
https://ncbi.nlm.nih.gov/pubmed/23355466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.427328
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