The Intrinsically Disordered Domain of the Antitoxin Phd Chaperones the Toxin Doc against Irreversible Inactivation and Misfolding

The toxin Doc from the phd/doc toxin-antitoxin module targets the cellular translation machinery and is inhibited by its antitoxin partner Phd. Here we show that Phd also functions as a chaperone, keeping Doc in an active, correctly folded conformation. In the absence of Phd, Doc exists in a relativ...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: De Gieter, Steven, Konijnenberg, Albert, Talavera, Ariel, Butterer, Annika, Haesaerts, Sarah, De Greve, Henri, Sobott, Frank, Loris, Remy, Garcia-Pino, Abel
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4256337/
https://ncbi.nlm.nih.gov/pubmed/25326388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.572396
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