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The Fic protein Doc uses an inverted substrate to phosphorylate and inactivate EF-Tu
Fic proteins are ubiquitous in all domains of life and play critical roles in multiple cellular processes through AMPylation of (transfer of AMP to) target proteins. Doc from the doc/phd toxin/antitoxin module is a member of the Fic family and inhibits bacterial translation by an unknown mechanism....
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3836179/ https://ncbi.nlm.nih.gov/pubmed/24141193 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1364 |
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