Llwytho...
Features of Protein-Protein Interactions that Translate into Potent Inhibitors: Topology, Surface Area and Affinity
Protein-protein interactions (PPIs) control the assembly of multi-protein complexes and, thus, these contacts have enormous potential as drug targets. However, the field has produced a mix of both exciting success stories and frustrating challenges. Here, we review known examples and explore how the...
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Fformat: | Artigo |
Iaith: | Inglês |
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2012
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Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3591511/ https://ncbi.nlm.nih.gov/pubmed/22831787 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1017/erm.2012.10 |
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