Selective and Potent Proteomimetic Inhibitors of Intracellular Protein–Protein Interactions**

Inhibition of protein–protein interactions (PPIs) represents a major challenge in chemical biology and drug discovery. α-Helix mediated PPIs may be amenable to modulation using generic chemotypes, termed “proteomimetics”, which can be assembled in a modular manner to reproduce the vectoral presentat...

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Bibliographic Details
Published in:Angew Chem Int Ed Engl
Main Authors: Barnard, Anna, Long, Kérya, Martin, Heather L, Miles, Jennifer A, Edwards, Thomas A, Tomlinson, Darren C, Macdonald, Andrew, Wilson, Andrew J
Format: Artigo
Language:Inglês
Published: WILEY-VCH Verlag 2015
Subjects:
Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4506525/
https://ncbi.nlm.nih.gov/pubmed/25651514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201410810
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