In vivo inhibition of trypanosome mitochondrial topoisomerase II: effects on kinetoplast DNA maxicircles.
Kinetoplast DNA, the mitochondrial DNA of trypanosomes, is a topologically complex structure composed of interlocked minicircles and maxicircles. We previously reported that etoposide, a potent inhibitor of topoisomerase II, promotes the cleavage of about 20% of network minicircle DNA (T. A. Shapiro...
Shranjeno v:
| izdano v: | Mol Cell Biol |
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| Principais autores: | , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Taylor & Francis
1994
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC359115/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8065322/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.14.9.5891-5897.1994 |
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