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In vivo inhibition of trypanosome mitochondrial topoisomerase II: effects on kinetoplast DNA maxicircles.

Kinetoplast DNA, the mitochondrial DNA of trypanosomes, is a topologically complex structure composed of interlocked minicircles and maxicircles. We previously reported that etoposide, a potent inhibitor of topoisomerase II, promotes the cleavage of about 20% of network minicircle DNA (T. A. Shapiro...

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Bibliografische gegevens
Hoofdauteurs: Shapiro, T A, Showalter, A F
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1994
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC359115/
https://ncbi.nlm.nih.gov/pubmed/8065322
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