Enhanced Antitumor Activity with Combining Effect of mTOR Inhibition and Microtubule Stabilization in Hepatocellular Carcinoma

Mammalian target of rapamycin (mTOR) and the microtubules are shown to be potential targets for treating hepatocellular carcinoma (HCC). PI3K/Akt/mTOR activation is associated with resistance to microtubule inhibitors. Here, we evaluated the antitumor activity by cotargeting of the mTOR (using allos...

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Detalhes bibliográficos
Main Authors: Zhou, Qian, Wong, Chi Hang, Lau, Cecilia Pik Yuk, Hui, Connie Wun Chun, Lui, Vivian Wai Yan, Chan, Stephen Lam, Yeo, Winnie
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3590758/
https://ncbi.nlm.nih.gov/pubmed/23509629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/103830
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