CRK protein binds to two guanine nucleotide-releasing proteins for the Ras family and modulates nerve growth factor-induced activation of Ras in PC12 cells.

It has been reported that growth factors activate Ras through a complex of an adaptor type SH2-containing molecule, Grb2, and a Ras guanine nucleotide-releasing protein (GNRP), mSos. We report on the involvement of another adaptor molecule, CRK, in the activation of Ras. Overexpression of wild-type...

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Hlavní autoři: Matsuda, M, Hashimoto, Y, Muroya, K, Hasegawa, H, Kurata, T, Tanaka, S, Nakamura, S, Hattori, S
Médium: Artigo
Jazyk:Inglês
Vydáno: 1994
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC359069/
https://ncbi.nlm.nih.gov/pubmed/8035825
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