CRK protein binds to two guanine nucleotide-releasing proteins for the Ras family and modulates nerve growth factor-induced activation of Ras in PC12 cells.

It has been reported that growth factors activate Ras through a complex of an adaptor type SH2-containing molecule, Grb2, and a Ras guanine nucleotide-releasing protein (GNRP), mSos. We report on the involvement of another adaptor molecule, CRK, in the activation of Ras. Overexpression of wild-type...

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Publié dans:	Mol Cell Biol
Auteurs principaux:	Matsuda, M, Hashimoto, Y, Muroya, K, Hasegawa, H, Kurata, T, Tanaka, S, Nakamura, S, Hattori, S
Format:	Artigo
Langue:	Inglês
Publié:	Taylor & Francis 1994
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC359069/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8035825/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.14.8.5495-5500.1994
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