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Critical binding and regulatory interactions between Ras and Raf occur through a small, stable N-terminal domain of Raf and specific Ras effector residues.

Genetic and biochemical evidence suggests that the Ras protooncogene product regulates the activation of the Raf kinase pathway, leading to the proposal that Raf is a direct mitogenic effector of activated Ras. Here we report the use of a novel competition assay to measure in vitro the relative affi...

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Bibliografische gegevens
Gepubliceerd in:Mol Cell Biol
Hoofdauteurs: Chuang, E, Barnard, D, Hettich, L, Zhang, X F, Avruch, J, Marshall, M S
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Taylor & Francis 1994
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC359051/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8035810/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.14.8.5318
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