Critical binding and regulatory interactions between Ras and Raf occur through a small, stable N-terminal domain of Raf and specific Ras effector residues.

Genetic and biochemical evidence suggests that the Ras protooncogene product regulates the activation of the Raf kinase pathway, leading to the proposal that Raf is a direct mitogenic effector of activated Ras. Here we report the use of a novel competition assay to measure in vitro the relative affi...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Cell Biol
Prif Awduron: Chuang, E, Barnard, D, Hettich, L, Zhang, X F, Avruch, J, Marshall, M S
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Taylor & Francis 1994
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC359051/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8035810/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.14.8.5318
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