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Impact of substrate protonation and tautomerization states on interactions with the active site of Arginase I

Human arginase is a binuclear manganese metalloenzyme that participates in the urea cycle. Arginase catalyses the hydrolysis of L-arginine into L-ornithine and urea and is linked to several disorders such as asthma and cancer. Currently, the protonation and tautomerization state of the substrate whe...

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Detaylı Bibliyografya
Asıl Yazarlar: Nagagarajan, Shanthi, Xue, Fengtian, MacKerell, Alexander D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3590304/
https://ncbi.nlm.nih.gov/pubmed/23327293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ci300506y
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