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Protonation of Trimethylamine N-Oxide (TMAO) is required for stabilization of RNA tertiary structure
The osmolyte trimethylamine N-oxide (TMAO) stabilizes the tertiary but not the secondary structures of RNA. However, molecular dynamics simulations performed on the PreQl riboswitch showed that TMAO destabilizes the tertiary riboswitch structure, leading us to hypothesize that the presence of RNA co...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3842377/ https://ncbi.nlm.nih.gov/pubmed/24012912 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpc.2013.08.002 |
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