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Impact of substrate protonation and tautomerization states on interactions with the active site of Arginase I
Human arginase is a binuclear manganese metalloenzyme that participates in the urea cycle. Arginase catalyses the hydrolysis of L-arginine into L-ornithine and urea and is linked to several disorders such as asthma and cancer. Currently, the protonation and tautomerization state of the substrate whe...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3590304/ https://ncbi.nlm.nih.gov/pubmed/23327293 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ci300506y |
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