Celastrol Suppresses Tumor Cell Growth through Targeting an AR-ERG-NF-κB Pathway in TMPRSS2/ERG Fusion Gene Expressing Prostate Cancer

The TMPRSS2/ERG (T/E) fusion gene is present in the majority of all prostate cancers (PCa). We have shown previously that NF-kB signaling is highly activated in these T/E fusion expressing cells via phosphorylation of NF-kB p65 Ser536 (p536). We therefore hypothesize that targeting NF-kB signaling m...

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Detalhes bibliográficos
Main Authors: Shao, Longjiang, Zhou, Zhansong, Cai, Yi, Castro, Patricia, Dakhov, Olga, Shi, Ping, Bai, Yaoxia, Ji, Huixiang, Shen, Wenhao, Wang, Jianghua
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3590152/
https://ncbi.nlm.nih.gov/pubmed/23554889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0058391
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