Highly specific targeting of the TMPRSS2/ERG fusion gene using liposomal nanovectors

PURPOSE: The TMPRSS2/ERG (T/E) fusion gene is present in half of all prostate cancer (PCa) tumors. Fusion of the oncogenic ERG gene with the androgen-regulated TMPRSS2 gene promoter results in expression of fusion mRNAs in PCa cells. The junction of theTMPRSS2 and ERG derived portions of the fusion...

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Bibliographic Details
Main Authors:	Shao, Longjiang, Tekedereli, Ibrahim, Wang, Jianghua, Yuca, Erkan, Tsang, Susan, Sood, Anil, Lopez-Berestein, Gabriel, Ozpolat, Bulent, Ittmann, Michael
Format:	Artigo
Language:	Inglês
Published:	2012
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3525716/ https://ncbi.nlm.nih.gov/pubmed/23052253 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-2715
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Highly specific targeting of the TMPRSS2/ERG fusion gene using liposomal nanovectors

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