Identification of Small Molecule Activators of Cryptochrome

Impairment of the circadian clock has been associated with numerous disorders, including metabolic disease. Although small molecules that modulate clock function might offer therapeutic approaches to such diseases, only a few compound have been identified that selectively target core clock proteins....

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Hauptverfasser: Hirota, Tsuyoshi, Lee, Jae Wook, St. John, Peter C., Sawa, Mariko, Iwaisako, Keiko, Noguchi, Takako, Pongsawakul, Pagkapol Y., Sonntag, Tim, Welsh, David K., Brenner, David A., Doyle, Francis J., Schultz, Peter G., Kay, Steve A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3589997/
https://ncbi.nlm.nih.gov/pubmed/22798407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1223710
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