Systematic repression of transcription factors reveals limited patterns of gene expression changes in ES cells

Networks of transcription factors (TFs) are thought to determine and maintain the identity of cells. Here we systematically repressed each of 100 TFs with shRNA and carried out global gene expression profiling in mouse embryonic stem (ES) cells. Unexpectedly, only the repression of a handful of TFs...

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Detalhes bibliográficos
Main Authors: Nishiyama, Akira, Sharov, Alexei A., Piao, Yulan, Amano, Misa, Amano, Tomokazu, Hoang, Hien G., Binder, Bernard Y., Tapnio, Richard, Bassey, Uwem, Malinou, Justin N., Correa-Cerro, Lina S., Yu, Hong, Xin, Li, Meyers, Emily, Zalzman, Michal, Nakatake, Yuhki, Stagg, Carole, Sharova, Lioudmila, Qian, Yong, Dudekula, Dawood, Sheer, Sarah, Cadet, Jean S., Hirata, Tetsuya, Yang, Hsih-Te, Goldberg, Ilya, Evans, Michele K., Longo, Dan L., Schlessinger, David, Ko, Minoru S. H.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3589720/
https://ncbi.nlm.nih.gov/pubmed/23462645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep01390
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