Uncovering early response of gene regulatory networks in ES cells by systematic induction of transcription factors

To examine transcription factor (TF) network(s), we created mouse ES cell lines, in each of which one of 50 TFs tagged with a FLAG moiety is inserted into a ubiquitously controllable tetracycline-repressible locus. Of the 50 TFs, Cdx2 provoked the most extensive transcriptome perturbation in ES cell...

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Detalhes bibliográficos
Main Authors: Nishiyama, Akira, Xin, Li, Sharov, Alexei A., Thomas, Marshall, Mowrer, Gregory, Meyers, Emily, Piao, Yulan, Mehta, Samir, Yee, Sarah, Nakatake, Yuhki, Stagg, Carole, Sharova, Lioudmila, Correa-Cerro, Lina S., Bassey, Uwem, Hoang, Hien, Kim, Eugene, Tapnio, Richard, Qian, Yong, Dudekula, Dawood, Zalzman, Michal, Li, Manxiang, Falco, Geppino, Yang, Hsih-Te, Lee, Sung-Lim, Monti, Manuela, Stanghellini, Ilaria, Islam, Md. Nurul, Nagaraja, Ramaiah, Goldberg, Ilya, Wang, Weidong, Longo, Dan L., Schlessinger, David, Ko, Minoru S. H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2770715/
https://ncbi.nlm.nih.gov/pubmed/19796622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2009.07.012
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