Neurokinin B Causes Acute GnRH Secretion and Repression of GnRH Transcription in GT1–7 GnRH Neurons

Genetic studies in human patients with idiopathic hypogonadotropic hypogonadism (IHH) identified mutations in the genes that encode neurokinin B (NKB) and the neurokinin 3 receptor (NK3R). However, determining the mechanism whereby NKB regulates gonadotropin secretion has been difficult because of c...

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Detalhes bibliográficos
Main Authors: Glidewell-Kenney, Christine A., Shao, Paul P., Iyer, Anita K., Grove, Anna M. H., Meadows, Jason D., Mellon, Pamela L.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2013
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3589675/
https://ncbi.nlm.nih.gov/pubmed/23393128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2012-1271
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