Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53.

The E6 oncoproteins of the cancer-associated or high-risk human papillomaviruses (HPVs) target the cellular p53 protein. The association of E6 with p53 leads to the specific ubiquitination and degradation of p53 in vitro, suggesting a model by which E6 deregulates cell growth control by the eliminat...

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Bibliografische gegevens

Gepubliceerd in:	Mol Cell Biol
Hoofdauteurs:	Huibregtse, J M, Scheffner, M, Howley, P M
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Taylor & Francis 1993
Onderwerpen:	Research Article
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC358960/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8380895/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.13.2.775-784.1993
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