Effects of Cyclic Intermittent Hypoxia on ET-1 Responsiveness and Endothelial Dysfunction of Pulmonary Arteries in Rats

Obstructive sleep apnoea (OSA) is a risk factor for cardiovascular disorders and in some cases is complication of pulmonary hypertension. We simulated OSA by exposing rats to cyclic intermittent hypoxia (CIH) to investigate its effect on pulmonary vascular endothelial dysfunction. Sprague-Dawley Rat...

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Main Authors: Wang, Zhuo, Li, Ai-Ying, Guo, Qiu-Hong, Zhang, Jian-Ping, An, Qi, Guo, Ya-jing, Chu, Li, Weiss, J. Woodrow, Ji, En-Sheng
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3589442/
https://ncbi.nlm.nih.gov/pubmed/23555567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0058078
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