Base-Resolution Analysis of 5-Hydroxymethylcytosine in the Mammalian Genome

The study of 5-hydroxylmethylcytosines (5hmC) has been hampered by the lack of a method to map it at single-base resolution on a genome-wide scale. Affinity purification-based methods cannot precisely locate 5hmC nor accurately determine its relative abundance at each modified site. We here present...

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Autori principali: Yu, Miao, Hon, Gary C., Szulwach, Keith E., Song, Chun-Xiao, Zhang, Liang, Kim, Audrey, Li, Xuekun, Dai, Qing, Park, Beomseok, Min, Jung-Hyun, Jin, Peng, Ren, Bing, He, Chuan
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3589129/
https://ncbi.nlm.nih.gov/pubmed/22608086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.04.027
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