Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation.

Phosphatidylinositol 3-kinase (PI 3-kinase) is stimulated by insulin and a variety of growth factors, but its exact role in signal transduction remains unclear. We have used a novel, highly specific inhibitor of PT 3-kinase to dissect the role of this enzyme in insulin action. Treatment of intact 3T...

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Publicado en:	Mol Cell Biol
Autores principales:	Cheatham, B, Vlahos, C J, Cheatham, L, Wang, L, Blenis, J, Kahn, C R
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Taylor & Francis 1994
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC358862/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8007986/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.14.7.4902-4911.1994
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