Specific activation of p85-p110 phosphatidylinositol 3'-kinase stimulates DNA synthesis by ras- and p70 S6 kinase-dependent pathways.

We have developed a polyclonal antibody that activates the heterodimeric p85-p110 phosphatidylinositol (PI) 3'-kinase in vitro and in microinjected cells. Affinity purification revealed that the activating antibody recognized the N-terminal SH2 (NSH2) domain of p85, and the antibody increased the ca...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	McIlroy, J, Chen, D, Wjasow, C, Michaeli, T, Backer, J M
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1997
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231749/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8972205/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.17.1.248
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